Utility of Supine vs. Upright vs. Upright Flexion/Extension C Spine Imaging in Diagnosing Craniocervical Instability (CCI)

Project description: Craniocervical instability (CCI), or increased mobility in the craniocervical junction, is common in hypermobility syndromes such as EDS/HSD. It can be debilitating or even life-threatening. However, the condition is often missed on imaging. This study will determine the utility of three imaging positions in identifying Craniocervical Instability (CCI): supine vs. upright vs. upright dynamic imaging (flexion/extension). Findings will be published in a top journal, and translated into a diagnostic imaging guide for craniocervical instability. Expected duration: __________.

Patient impact: Many patients with EDS/HSD and CCI are told their brain and spine imaging is normal. This contributes to delayed diagnosis, and in many cases, deteriorating health. To facilitate timely diagnosis, patients and providers need accurate, effective imaging guidelines. By comparing the efficacy of different types of imaging, we will develop that standard, and share it widely with health professionals.